Abstract Library
Members may log into MY ENETS to visit the abstract library from previous ENETS conferences.
Participants of the ENETS Conference in 2024 can now access the abstract booklet, e-posters and videos, slide decks of talks, the poster carousel, and more via My ENETS.
ENETS Abstract Search
#3320 TGF-β increase caspase activation and migration in typical bronchial carcinoids
Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.
Conference: 18th Annual ENETS Concerence (2021)
Presenting Author: Gagliardi I
Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,
Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,
#2910 Virotherapy Shows Promising Efficacy in Neuroendocrine Cancers
Introduction: So far, there have been only two clinical studies using virotherapeutics to treat neuroendocrine cancers (NCT00314925 & NCT02749331). Notably, none of these approaches employed a clinically approved virotherapeutic compound.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Lauer U
Authors: Lauer U, Berchtold S, Smirnow I, Schaller M, Fehrenbacher B,
Keywords: neuroendocrine, cancer, virotherapy, virotherapeutics, preclinical, research,
Introduction: Dysregulation of the mTOR pathway in digestive neuroendocrine tumours (d-NETs) led to the introduction of Everolimus (EVE) as treatment. EVE significantly increases PFS, but most patients acquire resistance, due to activation of feedback loops.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Capurso G
Authors: Terracciano F, Capone A, Montori A, Pilozzi E, Arcidiacono P,
Keywords: mTOR, Myc, resistance, pathway, RNA-seq,
Introduction: Specific components of ghrelin-system are associated with tumor development/ progression. We have previously described the presence of this system in neuroendocrine tumors (NETs) but clinical-molecular correlations have not been elucidated yet.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Herrera-Martinez A
Authors: Herrera-Martínez A, Gahete M, Sánchez-Sánchez R, Ortega Salas R, Serrano R,
Keywords: GEP-NET, ghrelin system, GOAT, GHSR1a, prognosis, invasion,
Introduction: Bronchial Carcinoids (BCs) are rare neuroendocrine neoplasms arising from respiratory epithelium. The only effective treatment option is surgery, but its efficacy is frequently limited by metastatic spread. Everolimus prolongs progression free survival but patients may develop resistance. Previous studies demonstrated that Everolimus reduces viability of NCI-H720 cells (Atypical Carcinoid) but not of NCI-H727 cells (Typical Carcinoid). Everolimus decreases Ciclyn D1 protein levels in both cell lines but NCI-H727 cells survive, indicating a derangement in cell cycle control.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author:
Authors: Bresciani G, Riva E, Ambrosio M, Zatelli M,
Keywords: bronchial carcinoids, cell cycle, cyclins, cdks, target therapy, everolimus, dinaciclib, palbociclib,